{"id":8088,"date":"2023-08-25T14:58:37","date_gmt":"2023-08-25T14:58:37","guid":{"rendered":"https:\/\/www.cellstemclinic.com\/?page_id=8088"},"modified":"2024-09-23T07:30:59","modified_gmt":"2024-09-23T07:30:59","slug":"stem-cell-secretome-therapy","status":"publish","type":"page","link":"https:\/\/www.cellstemclinic.com\/it\/stem-cell-secretome-therapy\/","title":{"rendered":"Stem Cell Secretome Therapy"},"content":{"rendered":"
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What is a Stem Cell Secretome? What are Exosomes ?<\/h1>\n<\/div>
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In scientific terms, the secretome is the totality of all substances released by stem cells to the outside. These include micro-vesicles, exosomes, proteins, cytokines (cell messengers), hormone-like substances and so-called immunomodulatory substances.<\/h3>\n

Based on current science, it is believed that the effect of stem cells in clinical trials conducted to date is not from the cells as such, but via the vesicles, protein molecules and other substances such as cytokines released by the cells. These substances released to the outside are called “the secretome” as an umbrella term, because the release is called secretion. Which substances of the secretome trigger the actual effects is still largely unknown. The Cell Stem Clinic secretome is produced from autologous mesenchymal stem cells.<\/h3>\n<\/div>
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Is Secretome the Same as Exosomes?<\/h1>\n<\/div>
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Secretome and exosomes are sometimes used as synonyms, but they are actually different.<\/h3>\n

The secretome is the totality of all messenger substances<\/strong> released to the outside, including the micro-vesicles and exosomes, but also other important factors that are dissolved in the fluid. These include many regeneration-promoting growth factors and so-called cytokines (cell-cell messengers).<\/h3>\n

Exosomes, on the other hand, are actually only the particulate exosomes <\/strong>that are isolated from the whole. Isolation concentrates them, but the important solutes and micro-vesicles are lost.<\/h3>\n<\/div>
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What is a Stem Cell Secretome Therapy?<\/h2>\n<\/div>
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Cell Stem Clinic’s stem cell secretome therapy is an experimental therapy that we use as part of individualized treatment for patients who may have a clear benefit from the therapy. In stem cell secretome therapy, stem cells are obtained from the patient’s own adipose tissue (autologous stem cells, adipose stem cells, adipogenic stem cells, ADSCs). This initial small number of stem cells is grown and expanded (multiplied) in the pharmaceutical clean-room laboratory. This allows to obtain significantly more stem cells than e.g. in BMC without propagation. The goal of this process is to increase the number of stem cells, induce the production of the potentially regenerative and anti-inflammatory substances that stem cells release to the outside, concentrate them and use them for treatment. Instead of implanting or injecting stem cells into the patient, only the produced cellular components, i.e. the secretome, are applied. Compared to direct injection of stem cells, the risks of this method are relatively lower.<\/h3>\n<\/div>
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Stem Cell Secretome Therapy: Advantages and Applications<\/h2>\n<\/div>
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