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About CellStemClinic therapy center

What is a Stem Cell Secretome? What are Exosomes ?

In scientific terms, the secretome is the totality of all substances released by stem cells to the outside. These include micro-vesicles, exosomes, proteins, cytokines (cell messengers), hormone-like substances and so-called immunomodulatory substances.

Based on current science, it is believed that the effect of stem cells in clinical trials conducted to date is not from the cells as such, but via the vesicles, protein molecules and other substances such as cytokines released by the cells. These substances released to the outside are called “the secretome” as an umbrella term, because the release is called secretion. Which substances of the secretome trigger the actual effects is still largely unknown. The Cell Stem Clinic secretome is produced from autologous mesenchymal stem cells.

Is Secretome the Same as Exosomes?

Secretome and exosomes are sometimes used as synonyms, but they are actually different.

The secretome is the totality of all messenger substances released to the outside, including the micro-vesicles and exosomes, but also other important factors that are dissolved in the fluid. These include many regeneration-promoting growth factors and so-called cytokines (cell-cell messengers).

Exosomes, on the other hand, are actually only the particulate exosomesthat are isolated from the whole. Isolation concentrates them, but the important solutes and micro-vesicles are lost.

What is a Stem Cell Secretome Therapy?

Cell Stem Clinic’s stem cell secretome therapy is an experimental therapy that we use as part of individualized treatment for patients who may have a clear benefit from the therapy. In stem cell secretome therapy, stem cells are obtained from the patient’s own adipose tissue (autologous stem cells, adipose stem cells, adipogenic stem cells, ADSCs). This initial small number of stem cells is grown and expanded (multiplied) in the pharmaceutical clean-room laboratory. This allows to obtain significantly more stem cells than e.g. in BMC without propagation. The goal of this process is to increase the number of stem cells, induce the production of the potentially regenerative and anti-inflammatory substances that stem cells release to the outside, concentrate them and use them for treatment. Instead of implanting or injecting stem cells into the patient, only the produced cellular components, i.e. the secretome, are applied. Compared to direct injection of stem cells, the risks of this method are relatively lower.

Stem Cell Secretome Therapy: Advantages and Applications

  • The Secretome is devoid of all cells, which will decrease the risk of unwanted reactions in allogenic use.

  • The Secretome has been tested in an autologous setting in hundreds of patients without any detrimental side effects.

  • Therapeutic doses can be achieved with as little as 1 million of mesenchymal stem cells.

  • The Stem Cell Secretome, once produced, is ready for use and can be stored at -80°C for up to 2 years.

  • Up to ten therapeutic doses of Stem Cell Secretome are available for a therapy course without renewed stem cell isolation.

  • Stem Cell Secretome therapy can be carried out at regular intervals over extended periods of time, e.g. at weekly intervals, providing a scheduled treatment plan instead of a single treatment at only one time point.

Applications

Stem Cell Secretome therapy is a novel therapy with regenerative effects in: 

 

  • Autoimmune Diseases:

  • Multiple Sclerosis (MS)

  • Rheumatoid Arthritis (RA)

  • Neurodegenerative Diseases:

  • Multiple Sclerosis (MS)

  • Parkinson’s Disease (PD)

  • Alzheimer’s Disease (AD)

  • Amyotrophic Lateral Sclerosis (ALS)

  • Orthopedics and Sport Injuries:

  • Osteoarthritis

  • Knee Injuries and Degeneration

  • Erectile Dysfunction, Impotence and Incontinence

  • Spinal Cord Injury (SCI)

  • Stroke

  • Cardiovascular Diseases

  • Liver and Kidney Diseases

  • and a few more upon request and after thorough evaluation

The best reward for CellStemClinic is successful treatment and improvements in our patients, their words of gratitude and smiles on their faces.

"We are very happy with the results of the treatment of our child. We keep in touch with the doctors at the clinic."

T. Bonetti , Switzerland

"We visit CellStemClinic on a regular basis, practically, every year. Having tried out various product propositions, we have always been happy about the quality of all treatments, their results, staff professionalism, ambiance and food. I would highly recommend the clinic to anyone who would like to pursue a more healthy and natural option of our regeneration process. My best wishes, Irina B."

Irini B., Moscow

"I’d like to express my deepest gratitude to all the CellStemClinic. I was pleasantly surprised when the doctors talked me through everything that was going on, explained why this or that particular action was taken, what kind of drugs were being administered and why they were prescribed in the first place, and what type of equipment they were using. Thank You"

Grace, Austria
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